Publications by authors named "R V Steenaard"
Objective: Hereditary pheochromocytoma (hPCC) commonly develops bilaterally, causing adrenal insufficiency when standard treatment, radical adrenalectomy (RA), is performed. Partial adrenalectomy (PA) aims to preserve adrenal function, but with higher recurrence rates. This study compares outcomes of PA versus RA in hPCC.
View Article and Find Full Text PDFBackground: Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism (VTE).
Objective: The aim was to evaluate the current management of new cases of CS with a focus on VTE and thromboprophylaxis.
Design And Methods: A survey was conducted within those that report in the electronic reporting tool (e-REC) of the European Registries for Rare Endocrine Conditions (EuRRECa) and the involved main thematic groups (MTG's) of the European Reference Networks for Rare Endocrine Disorders (Endo-ERN) on new patients with CS from January 2021 to July 2022.
Article Synopsis
- Stage IV adrenocortical carcinoma (mACC) has a historically poor prognosis, but results from a 2012 trial led to the recommendation of the first-line treatment EDP-M, which includes multiple chemotherapy agents.
- Analysis of data from 167 mACC patients in the Netherlands showed that while EDP-M appeared to improve overall survival (OS) numerically, the results were not statistically significant; patients receiving mitotane alone had the best long-term survival rates.
- Overall survival for mACC patients in the Netherlands has improved since 2014, with factors like palliative adrenalectomy and local treatment contributing to better outcomes, but EDP-M did not show a significant impact on OS.