Publications by authors named "R V Searles"
Maternal obesity puts the offspring at high risk of developing obesity and cardio-metabolic diseases in adulthood. Here, we utilized a mouse model of maternal high-fat diet (HFD)-induced obesity that recapitulates metabolic perturbations seen in humans. We show increased adiposity in the offspring of HFD-fed mothers (Off-HFD) when compared to the offspring regular diet-fed mothers (Off-RD).
View Article and Find Full Text PDFMaternal obesity puts the offspring at high risk of developing obesity and cardio-metabolic diseases in adulthood. Here, using a mouse model of maternal high-fat diet (HFD)-induced obesity, we show that whole body fat content of the offspring of HFD-fed mothers (Off-HFD) increases significantly from very early age when compared to the offspring regular diet-fed mothers (Off-RD). We have previously shown significant metabolic and immune perturbations in the bone marrow of newly-weaned offspring of obese mothers.
View Article and Find Full Text PDFMale rhesus monkeys ( = 24) had a biopsy of prefrontal cortical area 46 prior to chronic ethanol self-administration ( = 17) or caloric control ( = 7). Fourteen months of daily self-administration (water vs. 4% alcohol, 22 h access/day termed "open-access") was followed by two cycles of prolonged abstinence (5 weeks) each followed by 3 months of open-access alcohol and a final abstinence followed by necropsy.
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- Approaches to chronic wound care differ significantly between developing and developed nations, with traditional remedies often used in poorer regions and advanced, costly treatments available in wealthier areas.
- A case involving a 60-year-old man who developed a worsening spider bite highlights challenges with inadequate initial treatment and the need for effective wound management strategies.
- While modern wound care products can lead to quicker healing and fewer complications, traditional methods can still be effective and more affordable when advanced options are not accessible.
Article Synopsis
- Acute myeloid leukemia (AML) is a challenging cancer with few treatment options, and the study combines ex vivo drug sensitivity with genomic data from 805 patients to better understand treatment responses.
- This research identifies key features influencing drug sensitivity, particularly focusing on the differentiation state of AML cells, which has implications for how they respond to therapy.
- Notably, the gene PEAR1 emerges as a strong predictor of survival in young AML patients, highlighting its potential role in guiding treatment decisions and future drug development.