Publications by authors named "R V Morey"
Genetic contributions to human cortical structure manifest pervasive pleiotropy. This pleiotropy may be harnessed to identify unique genetically-informed parcellations of the cortex that are neurobiologically distinct from functional, cytoarchitectural, or other cortical parcellation schemes. We investigated genetic pleiotropy by applying genomic structural equation modeling (SEM) to map the genetic architecture of cortical surface area (SA) and cortical thickness (CT) for 34 brain regions recently reported in the ENIGMA cortical GWAS.
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- Uveal melanoma (UM) is a serious cancer with limited treatment options, and this study investigates the effects of imipridones, which activate a protein called CLPP that can indirectly inhibit a harmful energy production process in the cancer cells.
- Researchers found that imipridones, specifically ONC201 and ONC212, reduce the growth and spread of UM cells in the lab and show promise in decreasing tumor size and increasing survival in animal models.
- The findings suggest that imipridones could be a new and effective treatment strategy for patients with metastatic uveal melanoma (mUM).
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- Researchers have created a detailed neuronal wiring diagram of the whole brain of a fruit fly (Drosophila melanogaster), mapping over 5 billion chemical synapses between more than 139,000 neurons, to better understand brain function.
- The study includes detailed annotations about various cell types, nerve pathways, and neurotransmitter identities, and the data is freely available for other researchers to use and explore.
- By analyzing synaptic pathways and connections, the project helps illustrate how neural structures relate to sensorimotor behaviors, paving the way for similar studies in other species.
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- * Analysis of three datasets revealed a 'PTSD circuit' involving the medial prefrontal cortex, amygdala, and anterolateral temporal lobe, especially in veterans with traumatic brain injuries.
- * Functional connectivity within this circuit was linked to PTSD symptoms and decreased after transcranial magnetic stimulation, suggesting it could be a key focus for future treatment trials.
Background: The risk of developing type 2 diabetes mellitus (T2DM) is up to 50% among women with gestational diabetes mellitus (GDM). However, diabetes education during and after pregnancy is limited. To bridge this gap, our team developed four training modules on GDM for nurses and community health workers.
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