Rhodamine based turn-on dual mode chemosensor for the selective recognition of nickel ions: practical and theoretical applications.

This work presents the development of a rhodamine-based colorimetric and turn-on fluorescent chemosensor (P1) designed for selective recognition of Ni ions. Chemosensor P1 exhibited remarkable sensitivity and selectivity for Ni ions, exhibiting clear colorimetric and fluorescence responses. The binding interactions were meticulously examined using UV-Vis.

Unlocking biological complexity: the role of machine learning in integrative multi-omics.

The increasing complexity of biological systems demands advanced analytical approaches to decode the underlying mechanisms of health and disease. Integrative multi-omics approaches use multi-layered datasets such as genomic, transcriptomic, proteomic, and metabolomic data to understand biological processes much more comprehensively compared to the single-omics analysis and to provide a comprehensive view of cellular and molecular processes. However, these integrative approaches have their own computational and analytical challenges due to the large volume and nature of multi-omics data.

Virus and Cell Specific HMGB1 Secretion and Subepithelial Infiltrate Formation in Adenovirus Keratitis.

A highly contagious infection caused by human adenovirus species D (HAdV-D), epidemic keratoconjunctivitis (EKC) results in corneal subepithelial infiltration (SEI) by leukocytes, the hallmark of the infection. To date, the pathogenesis of corneal SEI formation in EKC is unresolved. HMGB1 (high-mobility group box 1 protein) is an alarmin expressed in response to infection and a marker of sepsis.

Unusual recurrence in advanced ovarian cancer after interval cytoreductive surgery and HIPEC.

Ovarian cancer is the second most fatal gynaecological malignancy. The relapses after treatment of ovarian cancer usually occur within 2 years after completion of the first-line therapy. Recurrent ovarian cancer commonly presents as peritoneal surface deposits in the abdomen with or without ascites.

The occurrence of follicular cyst affects the embryonic developmental competences of buffalo oocytes under in vitro culture conditions.

Cystic ovarian disease (COD) is a major cause of infertility in dairy cows. This study aimed to investigate the impact of follicular cysts on the invitro blastocyst developmental competence of oocytes and the relative gene expression of blastocysts developed from the subordinate follicles of ipsilateral (ovary with cyst), contralateral (ovary opposite to cyst), and normal ovaries of buffaloes. A total of 2059 ovaries were collected from slaughterhouse and classified into three categories based on the presence of follicular cysts: a) ipsilateral, b) contralateral, and c) control (absence of cysts).