Publications by authors named "R V Klementeva"
Article Synopsis
- Dose-intensive therapies during allogeneic hematopoietic stem cell transplantation (allo-HSCT) significantly disrupt gut microbiota and promote antibiotic resistance, with recovery patterns poorly understood.
- In a study of 12 adult patients, stool samples revealed a marked decline in microbial diversity starting from day 0, persisting for up to a year, with specific bacterial genera showing slower recovery.
- A rise in antibiotic-resistant bacteria was observed around day 30 post-transplant, with resistance to major antibiotic classes, but a gradual decrease in resistance levels was noted over the following year.
Article Synopsis
- A pilot clinical study showed that oral microbiota transplantation from a healthy mother to her 6-month-old child with neuroblastoma can safely prevent chemotherapy-induced oral mucositis.
- The patient received oral donor saliva during chemotherapy cycles, which led to a significant reduction in the severity of oral mucositis, only experiencing mild symptoms after hematopoietic cell transplantation.
- The study also revealed changes in the patient's oral bacteria, with an increase in beneficial bacteria and a decrease in harmful strains, and no adverse effects from the transplantation were reported.
Aim: Was to evaluate clinical efficacy, adverse events and changes in the gut microbiome after fecal microbiota transplantation (FMT) in patients with gastrointestinal (GI) form of graft-versus-host disease (GVHD).
Materials And Methods: The prospective single-center study in R.M.
Background: Fecal microbiota transplantation (FMT) has been recently approved by FDA for the treatment of refractory recurrent clostridial colitis (rCDI). Success of FTM in treatment of rCDI led to a number of studies investigating the effectiveness of its application in the other gastrointestinal diseases. However, in the majority of studies the effects of FMT were evaluated on the patients with initially altered microbiota.
View Article and Find Full Text PDFThe objective of the present work was to study the possibility and technical peculiarities of planned tracheotomy in the hematological patients with thrombocytopenia and coagulopathy suffering severe concomitant pathology. A total of 45 tracheotomies were performed in hematological patients during the period from 2009 till July 2012. The case histories of 32 patients were available for the retrospective analysis.
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