Publications by authors named "R V Iozzo"
Article Synopsis
- Proteoglycans like biglycan (Bgn) and decorin (Dcn) are crucial for bone health, primarily by attracting water through their unique structures, but their specific functions are not fully understood.
- Research using knockout mouse models revealed that Bgn deficiency leads to significant bone loss and reduced resilience, while Dcn appears to have a less pronounced impact, although it compensates when Bgn is absent.
- Both Bgn and Dcn are essential for important signaling pathways in bone maintenance, with Bgn playing a dominant role in preserving bone structure and hydration levels.
Background: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood.
Methods: We used a variety of rodent and human experimental model systems to determine whether exercise training can reduce tumor burden in breast cancer and to identify mechanism associated with any exercise training effects on tumor burden.
Results: We show that voluntary wheel running slows tumor development in the mammary specific polyomavirus middle T antigen overexpression (MMTV-PyMT) mouse model of breast cancer but only when mice are not housed alone.
Anti-angiogenic therapy is an established method for the treatment of several cancers and vascular-related diseases. Most of the agents employed target the vascular endothelial growth factor A, the major cytokine stimulating angiogenesis. However, the efficacy of these treatments is limited by the onset of drug resistance.
View Article and Find Full Text PDFDecorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression.
Proc Natl Acad Sci U S A
April 2024
Article Synopsis
- Decorin is a special type of protein made by cells in tumors that can stop cancer cells from growing by affecting certain signals in the body.
- Scientists found that when decorin is given to mice with breast cancer, it reduces the development of lymphatic vessels, which help tumors spread.
- The research suggests that decorin could be a new treatment to slow down or stop the growth of breast cancer by blocking these pathways.