[Effect of dosed diet restriction on physiological remodeling and bioelectric properties of bone].

The effect of dosed diet restriction on the physiological remodeling and bioelectric properties of bone tissue was studied in 48 male Wistar rats 3- and 18-months of age. The rate of bone tissue apposition was studied by the dynamic histomorphometry method (intravital tetracycline labeling). Electric potentials on the periosteal surface of the freshly isolated femurs were recorded.

[The influence of hyperoxic gas mixture on the respiratory part of the lungs in rats].

The respiratory part of the lungs was investigated in rats of 3 and 12 months of age before and after the influence of normobaric hyperoxic gas mixture (40 % and 90 % oxygen). We found the reduction in middle diameter, depth, cross-sectional area, width of the entrance to alveolus and the total width of respiratory bronchioles, alveolar ducts and sacs after 28 daily hyperoxic sessions (60 mines each). We detected increasing the amount of collagen fibers, the alveolar wall thickness and oxyproline concentration in a lung after breathing the hyperoxic gas mixture.

[The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster].

As a result of resistance test to hypoxia of Drosophilas melanogaster of Oregon strain, we identified a high resistance (Group II) and low resistance (Group III) subpopulations of flies. Flies from groups II and III were incubated in a constant normobaric hypoxia (Po2=62-64 mm Hg) for 10 generations. A highly resistant group (Group IV) were exposed to a shortterm anoxia (Po,=1,5 mm Hg, 5 min) every generation.

[Determination of age-related liver stiffness changes in rats according to the ultrasonic shear wave elastography].

We examined by ultrasound shear wave elastography (SWE) changes of liver stiffness (LS) in three groups rats of different ages. LS measurement by SWE was performed on "Ultima PA" equipment ("Radmir", Kharkov, Ukraine) with a 10-5 MHz linear transducer. To assess the functional state of the liver at the same time we studied age-related biochemical and morphological differences in the liver.

[The influence of normobaric hypoxia on the morphofunctional changes of thyroid gland in young rats].

We investigated the influence of hypoxic gas mixture (the different modes) on the morphometric indexes of thyroid gland functional activity in 3-mounth rats. It was shown a decrease in the size of follicles of middle area and the colloid and an increase in the amount of thyrocytes in a follicle, resorption vacuoles and interfollicular epithelium after exposure to hypoxic gas mixture (10% oxygen). We also detected an increase in a follicle-colloid index and a decrease in the colloid accumulation index.