Publications by authors named "R V Hay"
Chromoblastomycosis, an implantation mycosis, is a neglected tropical disease that causes decreased quality of life, stigma, and disability. The global burden of disease is unknown and data on disease epidemiology and outcomes are severely limited by a lack of access to needed diagnostic tools and therapeutics. The World Health Organization outlined targets for chromoblastomycosis in the Road Map for Neglected Tropical Diseases 2021-2030, but little progress has been made in initiating and implementing an effective control program globally.
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- Small-molecule degraders can effectively target and degrade disease-driving proteins, offering a new approach for treating previously untreatable conditions.
- Researchers used cryo-EM to observe how the degrader MZ1 helps position the Brd4 protein for ubiquitination by the UBE2R1 enzyme, leading to its degradation.
- The study identifies specific lysines on Brd4 that are prone to ubiquitination and suggests a flexible model for how degrader-induced targets could be modified for better drug development.
Scabies.
Deepani D Fernando Kate E Mounsey Charlotte Bernigaud Nuzhat Surve Guadalupe E Estrada Chávez Roderick J Hay
Nat Rev Dis Primers
October 2024
Article Synopsis
- Scabies is a highly contagious skin disease affecting over 200 million people globally, especially children in poor and crowded areas, leading to significant health issues.
- The lack of a vaccine and limited treatment options, like topical permethrin and oral ivermectin, often results in treatment failures due to fast-acting parasites and the need for multiple treatments.
- Addressing scabies requires a comprehensive strategy, focusing on better diagnostic tools, new treatments, enhanced surveillance, and raising public awareness to break the cycle of infection.
Article Synopsis
- * Researchers used advanced techniques to identify various Candida species from 300 samples and categorized them based on their ability to produce biofilms, finding that a significant percentage displayed low sensitivity to common antifungal drugs like fluconazole and nystatin.
- * The findings suggest that new antifungal agents or combinations with natural products could be promising alternatives for treating RVVC, given the challenges posed by existing medications.