Publications by authors named "R V Guha"
Introduction: Competency-based Medical Education (CBME) was introduced in the year 2019 in India. It has brought about major changes in medical education. The curriculum is learner centric, outcome based, focuses on the development of core competencies and professionalism.
View Article and Find Full Text PDFNear-infrared (NIR) emitters with high two-photon absorption (2PA) cross-sections are of interest to enable imaging in the tissue transparency windows. This study explores the potential of DNA-stabilized silver nanoclusters (Ag -DNAs) as water-soluble two-photon absorbers. We investigate 2PA of four different atomically precise Ag -DNA species with far-red to NIR emission and varying nanocluster and ligand compositions.
View Article and Find Full Text PDFObjective: To develop age-appropriate nonaGEnaRIan And cenTenarian suRgICal (GERIATRIC) risk tool for classifying patients who may or may not develop postoperative complications or die within their index hospital admission.
Background: There are no validated perioperative risk stratification tools for use in nonagenarian and centenarian patients-people aged 90 to 99 years and >100 years.
Methods: In this retrospective observational study, nonagenarians and centenarians undergoing any surgical procedure were profiled.
Salmonella enterica serotype Typhimurium (Salmonella) resides and multiplies intracellularly in cholesterol-rich compartments called Salmonella-containing vacuoles (SCVs) with actin-rich tubular extensions known as Salmonella-induced filaments (SIFs). SCV maturation depends on host-derived cholesterol, but the transport mechanism of low-density lipoprotein (LDL)-derived cholesterol to SCVs remains unclear. Here we find that peroxisomes are recruited to SCVs and function as pro-bacterial organelle.
View Article and Find Full Text PDFArticle Synopsis
- DNA-stabilized silver nanoclusters (Ag-DNAs) have flexible structures and light-emitting properties, but their chemical transformations are not fully understood.
- A study used mass spectrometry to analyze the breakdown products of 21 types of Ag-DNAs, revealing that they can lose silver atoms and transition to states with fewer effective valence electrons.
- Results indicated that Ag-DNAs stabilized by three DNA strands fragment more than those with two, and fragmentation patterns vary based on the DNA sequence, with simulations confirming that initial breakup respects electron-pairing rules.