MARKERS OF THE PROSTATE BASAL LAYER CELLS ARE EFFECTIVE INDICATORS OF ITS MALIGNANT TRANSFORMATION.

Development of local or general forms of prostate cancer (PC) depends on formation of metastasis the biological nature of which is based on epithelial mesenchymal transition (EMT). ÅÌÒ presents highly conservative reversible program that is maintained by specific transcription factors which suppress E-cadherin expression and support production of mesenchymal polarity factors. The goal of this work was to study the functionally distinct markers in malignant prostate tissue of patients with prostate cancer using the histological evaluation, reverse polymerase chain reaction and immunobloting.