Ionic Liquid Catalysis in Cyclic Carbonate Synthesis for the Development of Soybean Oil-Based Non-Isocyanate Polyurethane Foams.

A method for obtaining non-isocyanate polyurethane (NIPU) foams from cyclic carbonate (CC) based on soybean oil was developed. For this purpose, cyclic carbonate was synthesized from epoxidized soybean oil and CO using various ionic liquids (ILs) as catalysts. Among the tested ILs, the highest selectivity (100%) and CC yield (98%) were achieved for 1-ethyl-3-methylimidazolium ([emim]Br).

Adverse event reporting practices in drug-resistant tuberculosis facilities across South Africa.

Background: The reporting of adverse drug reactions associated with drug-resistant tuberculosis (DR-TB) medication is important for pharmacovigilance, especially in high-burden countries such as South Africa. With DR-TB treatment being so dynamic, it is important to understand adverse event reporting practices at specialised facilities.

Objectives: The study aimed to understand the adverse drug reaction (ADR) reporting practices at DR-TB treatment facilities in South Africa.

Vaccine hesitancy and related factors among South African adults in 2021: unpacking uncertainty versus unwillingness.

Background: Amidst widespread public health recommendations and availability of COVID-19 vaccinations, half of South African adults are vaccinated against COVID-19. This study investigated the socio-behavioral determinants of vaccine hesitancy in South Africa, where vaccine hesitancy was separated into unwilling ness and uncertainty to take a COVID-19 vaccine.

Methods: Data was collected from a large-scale public survey during June-October 2021 that included online and telephonic surveys.

Nanoformulation of a novel potent ebselen analog for treatment of vulvovaginal candidiasis.

Vulvovaginal candidiasis is primarily caused by (). Here, a novel organoselenium compound (G20) was synthesized and evaluated for anti- activity. Growth-inhibition studies and medium acidification assays to assess the inhibition of the yeast plasma membrane H-ATPase (Pma1p) were carried out using G20.

Chiral 2-azabicycloalkanes bearing 1,2,3-triazole, thiourea, and ebselen moieties - Synthesis and biological activity.

2-Azabicycloalkanes: 2-azabicyclo[2.2.1]heptane and 2-azabicyclo[3.