Basic Science and Pathogenesis.

Background: Cognitive decline is often influenced by Alzheimer's disease (AD) pathology (e.g., beta-amyloid burden) and other pathology (e.

Using positionality and reflexivity to support equity in partnership-driven research.

Social and economic position and power shape everyone, including scientists and researchers. The way researchers do conservation science and the voices centered in the process are a result of researcher upbringing, experiences, access to resources, and values and are a manifestation of positionality. Positionality is a concept that can help one think about one's position and power in one's work.

CSF dynamics throughout the ventricular system using 4D flow MRI: associations to arterial pulsatility, ventricular volumes, and age.

Background: Cerebrospinal fluid (CSF) dynamics are increasingly studied in aging and neurological disorders. Models of CSF-mediated waste clearance suggest that altered CSF dynamics could play a role in the accumulation of toxic waste in the CNS, with implications for Alzheimer's disease and other proteinopathies. Therefore, approaches that enable quantitative and volumetric assessment of CSF flow velocities could be of value.

Functional xenon-129 magnetic resonance imaging response to antifibrotic treatment in idiopathic pulmonary fibrosis.

https://bit.ly/3ZXipzD.

Trajectory of clinical symptoms in relation to amyloid chronicity.

Introduction: While it is generally appreciated that amyloid precedes symptomatic Alzheimer's disease (AD) by decades, a greater understanding of this timeline may increase prognostic accuracy, planning, and care of persons who are on the AD continuum.

Methods: We examined trajectories of Clinical Dementia Rating-Sum of Boxes (CDR-SB) relative to estimated years of amyloid positivity (A+) in  = 123 participants who were all A+ based on [C-11]Pittsburgh compound B positron emission tomography.

Results: The average amyloid chronicity at CDR-SB of 2.