Publications by authors named "R Uhlig"
Background/objectives: Carcinoembryonic antigen (CEA) is a cell-surface glycoprotein serving as a drug target, diagnostic marker, and serum marker for cancer monitoring. However, prevalence data on CEA expression in cancer tissues vary considerably. This study was designed to determine CEA expression in normal and neoplastic tissues.
View Article and Find Full Text PDFContext.—: Steroidogenic acute regulatory (StAR) protein is a mitochondrial transport protein with a critical regulatory role for steroid hormone production. The tissue distribution of StAR expression is limited to few human normal tissues.
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- GAD2 is a key inhibitory neurotransmitter found mainly in brain and pancreatic islet cells, making it a potential diagnostic marker for tumors.
- In an analysis of over 19,000 samples from various tumors and normal tissues, GAD2 expression was identified in a small percentage of tumor categories, particularly in neuroendocrine cancers.
- Combining GAD2 with progesterone receptor (PR) testing enhances diagnostic accuracy for determining pancreatic origins of neuroendocrine neoplasms, achieving high sensitivity and specificity.
Article Synopsis
- * The study found that INSM1 was positive in 89.2% of neuroendocrine neoplasms, but only 3.5% of non-neuroendocrine tumors, with some cases of occasional weak expression observed in various non-neuroendocrine tumors.
- * When combined with other markers (synaptophysin and chromogranin A), INSM1 improved the sensitivity for detecting neuroendocrine differentiation in tumors, particularly in neuroendocrine carcinomas, demonstrating its efficacy as an