A vision-language foundation model for precision oncology.

Clinical decision-making is driven by multimodal data, including clinical notes and pathological characteristics. Artificial intelligence approaches that can effectively integrate multimodal data hold significant promise in advancing clinical care. However, the scarcity of well-annotated multimodal datasets in clinical settings has hindered the development of useful models.

Integrating gene therapy into the treatment paradigm for non-muscle invasive bladder cancer.

Introduction: Approximately 75% of bladder cancer cases are non-muscle invasive at diagnosis. Drug development for non-muscle invasive bladder cancer (NMIBC) has historically lagged behind that of other malignancies. No treatment has demonstrated the ability to overcome drug resistance that ultimately leads to recurrence and progression.

Design of boron nitride/nanocellulose aerogel-stabilized phase change materials for efficient thermal energy capture and storage.

The practical application of polyethylene glycol (PEG) phase change materials (PCMs) necessitates exceptional shape stability, rapid thermal responsiveness, and a substantial thermal storage capacity. The present study focuses on the fabrication of a highly robust cellulose nanofibril (CNF) based aerogel with an ordered structure, serving as a three-dimensional (3D) scaffold for PEG to effectively prevent any potential leakage. Additionally, hydroxyl and amino functional groups are introduced to functionalize boron nitride nanosheets (BNNS-g), which are incorporated into the aerogel to enhance its thermal conductivity.

Genomic Selection and WssGWAS of Sheep Body Weight and Milk Yield: Imputing Low-Coverage Sequencing Data with Similar Genetic Background Panels.

Low-coverage whole-genome sequencing (LcWGS), a cost-effective genotyping method, offers greater flexibility in variant detection than does single-nucleotide polymorphism (SNP) chips. However, to our knowledge, no studies have explored the application of LcWGS in sheep. This study aimed to evaluate the feasibility of implementing LcWGS and genotype imputation and assess their applicability in genomic studies of body weight and milk yield in sheep.

The hygienic insecticide dimefluthrin induced neurodevelopmental deficits and behavioral disorders in zebrafish (Danio rerio) larvae.

Hygienic insecticides are applied directly to the living environment and are closely related to human life. Dimefluthrin (DIM) is one of the most widely used hygienic insecticides globally. However, with increasing mosquito resistance, both the concentration and duration of DIM usage have risen, prompting public concerns regarding its neurotoxic risks, especially for immunocompromised children.