Publications by authors named "R U Lemieux"
Article Synopsis
- The study explores how specific arrangements of chiral centers in bent-core molecules influence the creation of various filament morphologies at the nanoscale.
- The research highlights the unexpected coexistence of different shapes, such as flat nanoribbons and twisted microfilaments, indicating spontaneous changes in structure along the filament's length.
- Findings reveal that adjusting the number and location of chiral centers can lead to a complete transformation of filament types, showcasing a wide diversity in morphology from flat ribbons to complex helical structures.
The birth of a child has been associated with a decline in couple satisfaction, which has implications for the child's social-emotional development. This study investigated the potential spillover effect on pregnant women's perceptions of their relationships with their partners of the Supporting the Transition to and Engagement in Parenthood (STEP) program, a brief trauma-informed mentalization-based prenatal group intervention. Participants (94% White) were recruited in prenatal clinics and through online advertisements in Quebec, Canada.
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- G3BP1 and G3BP2 are proteins that help form stress granules in cells during stress, like viral infections, but SARS-CoV-2's nucleocapsid (N) protein stops this process.
- The study identifies a specific mutation (N-F17A) in the N protein that prevents its interaction with G3BP1/2, leading to an inability to inhibit stress granule formation.
- This disruption results in lower viral replication and reduced illness in experimental models, showing that the G3BP1-N interaction is crucial for SARS-CoV-2’s ability to replicate and cause disease.
Article Synopsis
- Childhood trauma includes various experiences beyond just abuse or neglect, and the study examines the effectiveness of a new tool called the Childhood Interpersonal Trauma Inventory (CITI) in measuring these experiences.
- The study involved 2,518 adults who completed the CITI and other established trauma measures, finding that the CITI effectively identifies a wide range of childhood traumas.
- Results showed that the CITI has good sensitivity and specificity for detecting maltreatment and is better at predicting psychiatric symptoms compared to traditional measures, highlighting its potential value in both research and clinical settings.
Stress granule formation is triggered by the release of mRNAs from polysomes and is promoted by the action of the RNA-binding proteins G3BP1/2. Stress granules have been implicated in several disease states, including cancer and neurodegeneration. Consequently, compounds that limit stress granule formation or promote their dissolution have potential as both experimental tools and novel therapeutics.
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