Publications by authors named "R Turrini"
Objective: To verify the effect of aromatherapy (inhaled or via the skin) with lavender, sweet orange and bergamot essential oils on caregivers' overload and fatigue.
Method: Pilot, quasi-experimental, randomized, non-blind and parallel study with two groups. The reduced Zarit Burden Interview and Revised Piper scales were used, comparing the effect of two routes of administration.
Article Synopsis
- Ofatumumab (OFA) and ocrelizumab (OCRE) are two monoclonal antibodies used to treat relapsing multiple sclerosis by targeting and depleting B lymphocytes.
- In a study using humanized mice, both OFA and OCRE resulted in over 90% reduction of circulating human CD20+ B lymphocytes, but only OFA showed signs of B lymphocyte replenishment after several weeks.
- OFA treatment preserved bone marrow niches necessary for B cell recovery, while OCRE only maintained preB-I cells, indicating OFA may have a more favorable safety profile regarding infection risk.
Background And Objectives: In multiple sclerosis (MS), MRI markers can measure the potential neuroprotective effects of fingolimod beyond its anti-inflammatory activity. In this study we aimed to comprehensively explore, in the real-word setting, whether fingolimod not only reduces clinical/MRI inflammatory activity, but also influences the progression of irreversible focal and whole brain damage in relapsing-remitting [RR] MS patients.
Methods: The "EVOLUTION" study, a 24-month observational, prospective, single-arm, multicenter study, enrolled 261 RRMS patients who started fingolimod at 32 Italian MS centers and underwent biannual neurological assessments and annual MRI evaluations.
Objective: To analyze the effectiveness of Bach flower therapy compared to placebo in reducing perceived stress levels in primary health care nursing professionals.
Method: Pragmatic, parallel randomized clinical trial conducted with 87 primary care nursing professionals with self-identified stress, from October 2021 to June 2022, in the cities of Osasco and São Paulo, Brazil. The intervention group (n=43) received the collective flower formula, and the placebo group (n=44) received only the diluent.
Expansion of antigen-experienced CD8 T cells is critical for the success of tumour-infiltrating lymphocyte (TIL)-adoptive cell therapy (ACT) in patients with cancer. Interleukin-2 (IL-2) acts as a key regulator of CD8 cytotoxic T lymphocyte functions by promoting expansion and cytotoxic capability. Therefore, it is essential to comprehend mechanistic barriers to IL-2 sensing in the tumour microenvironment to implement strategies to reinvigorate IL-2 responsiveness and T cell antitumour responses.
View Article and Find Full Text PDF