A universal calibration framework for mixed-reality assisted surgery.

Background: Mixed-reality-assisted surgery has become increasingly prominent, offering real-time 3D visualization of target anatomy such as tumors. These systems facilitate translating preoperative 3D surgical plans to the patient's body intraoperatively and allow for interactive modifications based on the patient's real-time conditions. However, achieving sub-millimetre accuracy in mixed-reality (MR) visualization and interaction is crucial to mitigate device-related risks and enhance surgical precision.

Comparison of Pathologic Tumor Necrosis of Conventional Versus Ultrahypofractionated Preoperative Radiation Therapy in Localized Extremity Soft Tissue Sarcoma and Its Correlation With Clinical Outcomes.

Purpose: We aimed to determine if ultrahypofractionated radiation therapy (UHYPO-RT) delivering 6 Gy x 5 fractions yields similar tumor necrosis compared with conventional radiation therapy (CONV-RT) with 2 Gy x 25 fractions in soft tissue sarcoma. The clinical significance of tumor necrosis on loco-regional recurrence-free survival (LRFS), distant disease-free survival (DDFS), and overall survival (OS) were assessed.

Methods And Materials: Patients with localized soft tissue sarcoma treated with CONV-RT or UHYPO-RT followed by surgery were included.

Taper Junction Subsidence Occurs in Modular Tumor Endoprostheses: How Concerned Should We Be?

Background: Advancements in musculoskeletal oncologic treatment have allowed for longer survival of patients with malignant bone tumors and the associated longer use of tumor endoprostheses in those who have had such reconstructions. Several studies have reported on increased serum metal ions with the use of such implants. Modularity in these implants introduces the risk of taper junction corrosion and subsidence resulting in metal wear particle release that may cause an adverse local tissue reaction or systemic toxicity.