Publications by authors named "R Trylcova"
Article Synopsis
- The study aimed to investigate the short-term effects of radiation on the rat forebrain by exposing adult male Wistar rats to fractionated doses of gamma rays.
- Immunohistochemistry and confocal microscopy were used to analyze the distribution of proliferating cells along specific areas of the brain, particularly in the subventricular zone and its pathway to the olfactory bulb.
- The findings revealed a varying rate of cell distribution, especially pronounced in certain areas, suggesting that the radiation response of these cells may contribute to negative long-term effects post-exposure.
Ionizing radiation can induce significant injury to normal brain structures. To assess radiation-induced late effects, adult male Wistar rats received whole-body exposure with fractionated doses of gamma rays (a total dose of 4Gy) and were investigated thirty, sixty and ninety days later. Immunohistochemistry and confocal microscopy were used to determine the density of neuroblasts derived from the anterior subventricular zone (SVZa) and brain resident microglia distributed along and/or adjacent to subventricular zone-olfactory bulb axis (SVZ-OB axis).
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