Publications by authors named "R Treadwell"
Objectives: Substance use disorders (SUDs) are characterized by impairment caused by the recurrent use of alcohol, illicit drugs, or both. SUDs are pervasive and endemic among US adolescents, with potentially negative health and social consequences. Although the term normalizes adolescent substance abuse, the long-term consequences of this behavior beginning in adolescence can be detrimental to not only the adolescent but also the adult into which he or she develops.
View Article and Find Full Text PDFRates of overweight and obesity are above 70% in typically developing adults in the United States, with higher rates observed in individuals diagnosed with developmental disability (DD). Lottery reinforcement systems have been validated as effective exercise interventions for individuals with DD. Although high-intensity interval training (HIIT) has demonstrated health benefits, it has not been studied using individuals within this population.
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- Multiple multicomponent reactions are effective at quickly creating complex structures but often lack selectivity and have limited transformations for wider use in synthesis.
- The study proposes a method to enhance selectivity by generating less reactive intermediates from the starting materials.
- By utilizing this selective approach with the Groebke-Blackburn-Bienaymé reaction, researchers successfully produced various compact heterocyclic compounds with significant potential for applications in medicinal and biological chemistry, such as probes for live cell imaging and antiviral agents.
An activatable BODIPY probe for in vitro detection and fluorescence cell imaging of free Mg without interference from Ca is described. Fluorescence amplification of the probe is observed upon detection of physiological concentrations of Mg due to reduced rotation of the fluorophore and effective chelation by a quinolizine-based core.
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