Unraveling the nutrition and health situation of adults in geographically isolated and disadvantaged areas (GIDA) and non-GIDA in the Philippines: A comparative study.

Geographically Isolated and Disadvantaged Areas (GIDA) are communities physically and socioeconomically separated from mainstream society (non-GIDA) and lack comprehensive nutrition and health assessments. This study aimed to assess the nutritional and health status and determine the factors associated with chronic energy deficiency (CED) and overweight/obesity among adults, 20-59 years old, residing in GIDA and non-GIDA. Data of the 20,381 adults collected in the Expanded National Nutrition Survey were analyzed.

Dysregulated Immune Responses in COVID-19 Patients Correlating With Disease Severity and Invasive Oxygen Requirements.

The prognosis of severe COVID-19 patients has motivated research communities to uncover mechanisms of SARS-CoV-2 pathogenesis also on a regional level. In this work, we aimed to understand the immunological dynamics of severe COVID-19 patients with different degrees of illness, and upon long-term recovery. We analyzed immune cellular subsets and SARS-CoV-2-specific antibody isotypes of 66 COVID-19 patients admitted to the Hospital Clínico Universidad de Chile, which were categorized according to the WHO ten-point clinical progression score.

HIV-1 resistance patterns to integrase inhibitors in Chilean patients with virological failure on raltegravir-containing regimens.

In this viewpoint we would like to describe our results in terms of resistance pattern in Chilean patients with virological failure (VF) on raltegravir (RAL)-containing-regimens and highlight the need for the concomitant availability of genotypic resistance testing to integrase strand transfer inhibitors (INSTIs) introduction in antiretroviral regimens, particularly in countries in South America. Indeed we found in our study the presence of two or more primary mutations in some of the participants which is associated with cross-resistance to all INSTIs. By using timely genotyping, we could optimally manage these patients, early after detection of VF.

Simulation-optimization methods for designing and assessing resilient supply chain networks under uncertainty scenarios: A review.

The design of supply chain networks (SCNs) aims at determining the number, location, and capacity of production facilities, as well as the allocation of markets (customers) and suppliers to one or more of these facilities. This paper reviews the existing literature on the use of simulation-optimization methods in the design of resilient SCNs. From this review, we classify some of the many works in the topic according to factors such as their methodology, the approach they use to deal with uncertainty and risk, etc.