Publications by authors named "R Tomioka"
The design of functional materials with desired properties is essential in driving technological advances in areas like energy storage, catalysis, and carbon capture. Generative models provide a new paradigm for materials design by directly generating novel materials given desired property constraints, but current methods have low success rate in proposing stable crystals or can only satisfy a limited set of property constraints . Here, we present MatterGen, a model that generates stable, diverse inorganic materials across the periodic table and can further be fine-tuned to steer the generation towards a broad range of property constraints.
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- The cortico-basal ganglia loop has been traditionally seen as three separate networks: motor, limbic, and associative, but this view doesn’t fully capture its complexity, especially in sensory processing like hearing.
- Recent research demonstrates an auditory-specific loop within this system using transgenic mice, identifying the caudal external globus pallidus (GPe) as a key output node.
- GABAergic neurons in the caudal GPe are crucial as they connect to various brain regions, suggesting these circuits could be important for triggering defensive responses to sounds.
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- Silver cluster-assembled materials (SCAMs) are specially designed crystalline materials known for their unique shapes and precise structures.
- This study introduces two types of SCAMs: a three-dimensional one (TUS 6) created using a tritopic linker, and a two-dimensional one (TUS 7), highlighting the innovative methods for synthesizing these materials.
- The research reveals how the addition of organic linkers changes the symmetry of silver nanoclusters, providing new insights into how these clusters transform into more complex structures.
Host cell protein (HCP) impurities are considered a critical quality attribute of biopharmaceuticals because of their potential to compromise safety and efficacy, and LC/MS-based analytical methods have been developed to identify and quantify individual proteins instead of employing enzyme-linked immunosorbent assay to assess total HCP levels. Native digestion enables highly sensitive detection of HCPs but requires overnight incubation to generate peptides, limiting the throughput of sample preparation. In this study, we developed an approach employing native digestion on a trypsin-immobilized column to improve the sensitivity and throughput.
View Article and Find Full Text PDFMalignant otitis externa (skull base osteomyelitis) can be fatal and long-term antibiotic therapy is recommended. Despite being potentially fatal, this infection causes minor changes in inflammatory biomarkers (white blood cell count and C-reactive protein levels) upon blood testing. Computed tomography and magnetic resonance imaging changes persist over a long period.
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