Publications by authors named "R Toledano"
Objectives: Tideglusib (Tx) is known for its osteogenic potential, yet its effects on the interplay between osteoblasts and M1 macrophages remain underexplored. This in vitro study aimed to isolate and evaluate both the individual and combined roles of M1 macrophages and osteoblasts in macrophage differentiation and osteoblast function, specifically focusing on how these interactions influence protein expression of osteogenesis and osteoclastogenesis in the presence or absence of Tx.
Methods: Osteoblast and macrophage cells were co-cultured in direct contact for 24 and 48 h, with or without the presence of Tx.
Article Synopsis
- Hippocampal sclerosis (HS) is a major cause of temporal lobe epilepsy (TLE) but can be hard to detect on MRI, leading to surgical delays, so researchers created open-source software to improve diagnosis.
- The study involved 365 participants, using the software HippUnfold to analyze MRI scans and develop a logistic regression model that accurately identifies and localizes HS.
- The classifier showed high accuracy in detecting HS in both initial and independent patient cohorts, proving effective for individual assessments by comparing patient data with normative growth patterns.
Intracranial potentials are used as functional biomarkers of neural networks. As potentials spread away from the source populations, they become mixed in the recordings. In humans, interindividual differences in the gyral architecture of the cortex pose an additional challenge, as functional areas vary in location and extent.
View Article and Find Full Text PDFObjectives: The aim of this study was to determine the viscoelastic performance and energy dissipation of conditioned dentin infiltrated with polymeric nanoparticles (NPs) doped with tideglusib (TDg) (TDg-NPs).
Methods: Dentin conditioned surfaces were infiltrated with NPs and TDg-NPs. Bonded interfaces were created, stored for 24 h and submitted to mechanical and thermal challenging.
Article Synopsis
- The study explored how polymeric nanoparticles containing tideglusib (TDg-NPs) affect the formation, crystallinity, and elasticity of the resin-dentin interfaces in teeth.
- Results showed that TDg-NPs led to higher crystallinity and improved mechanical properties compared to undoped nanoparticles, with better aligned hydroxyapatite crystals.
- Although the TDg-NPs initiated effective mineralization, thermal stress negatively impacted the functional mineralization and crystallinity of the treated dentin.