Publications by authors named "R Thissen"

Article Synopsis
  • The study focuses on the lesser-known phenomenon of oligogenic coinheritance, where individuals carry multiple heterozygous pathogenic variants (PVs) related to cancer, as opposed to the more commonly researched single gene carriers.
  • Researchers examined 10 patients aged 45 or younger who had multiple primary cancers (MPCs) and used advanced genetic testing methods such as whole exome sequencing (WES) and chromosomal microarray analysis (CMA) to identify genetic variations associated with their conditions.
  • The findings revealed that most genetic variants were of uncertain significance, indicating potential additive effects in cancer development, and emphasized the need for comprehensive assessments that go beyond just identifying one PV in patients with early-onset cancers and a family history of
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Interest in the observation and characterization of organic isomers in astronomical environments has grown rapidly with an increase in the sensitivity of detection techniques. Accurate modeling and interpretation of these environments require experimental isomer-specific reactivity and spectroscopic measurements. Given the abundance of formaldehyde (HCO) in various astrophysical objects, the properties and reactivities of its cation isomers HCO and HCOH are of significant interest.

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The gas phase reactivity of the radical cation isomers HCNH˙ (methanimine) and HCNH˙ (aminomethylene) with propene (CHCHCH) has been investigated by measuring absolute reactive cross sections and product branching ratios, under single collision conditions, as a function of collision energy (in the range ∼0.07-11.80 eV) using guided ion beam mass spectrometry coupled with VUV photoionization for selective isomer generation.

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We report a study on the reactive collision of S+(4S) with H2, HD, and D2 combining guided ion beam experiments and quantum-mechanical calculations. It is found that the reactive cross sections reflect the existence of two different mechanisms, one being spin-forbidden. Using different models, we demonstrate that the spin-forbidden pathway follows a complex mechanism involving three electronic states instead of two as previously thought.

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