Evidence-based clinical practice guideline for management of urinary tract infection and primary vesicoureteric reflux.

We present updated, evidence-based clinical practice guidelines from the Indian Society of Pediatric Nephrology (ISPN) for the management of urinary tract infection (UTI) and primary vesicoureteric reflux (VUR) in children. These guidelines conform to international standards; Institute of Medicine and AGREE checklists were used to ensure transparency, rigor, and thoroughness in the guideline development. In view of the robust methodology, these guidelines are applicable globally for the management of UTI and VUR.

Combined saposin deficiency: A rare occurrence.

Combined saposin deficiency (OMIM #611721), an exceedingly rare lysosomal storage disorder, is caused by a mutation in the gene . This gene encodes a protein, prosaposin, that cleaves into four constituent proteins, each of which has a role as a cofactor for the enzymes whose deficiency results in Krabbe disease, metachromatic leukodystrophy, Gaucher disease, and Farber disease, respectively. Intact prosaposin itself is essential for neuronal survival.

Consensus Guidelines on Management of Steroid-Resistant Nephrotic Syndrome.

Justification: The management of steroid resistant nephrotic syndrome (SRNS) is challenging. These guidelines update existing 2009 Indian Society of Pediatric Nephrology recommendations on its management.

Objective: To frame revised guidelines on diagnosis and evaluation, treatment and follow up, and supportive care of patients with the illness.

Enuresis, Lower Urinary Tract Dysfunction and Teachers' Perceptions: A School-based Survey.

Objective: To determine the prevalence of enuresis and lower urinary tract dysfunction among Indian school children, and describe teachers' perceptions regarding toilet requests.

Methods: Anonymous survey of students of a secondary school in Visakhapatnam, India by a modified version of the Dysfunctional voiding and incontinence scoring system (DVISS) in 2518 parents. Two questionnaires - the Bathroom behaviour scale and Teachers' hassle scale for toilet requests were designed, validated and administered to 138 teachers.