Publications by authors named "R Teufel"
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.
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- Pediatrics is a dynamic field where clinicians can develop research to enhance evidence-based practices, yet they often find it challenging to juggle both education and clinical care.
- New faculty members face particular difficulties in initiating their first research projects due to limited experience, resources, and team development.
- The manuscript provides 10 key reflections to help newcomers navigate their first research projects and build a strong foundation to prevent common mistakes.
Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin.
Angew Chem Int Ed Engl
December 2024
Prymnesin toxins were probably the direct cause of the environmental catastrophe in the Oder river in 2022. They belong to the so-called ladder polyethers, which are among the most toxic non-proteinogenic substances and have caused a whole series of food poisoning in humans and numerous other incidents of fish deaths. Despite massive efforts, the enzymatic machinery has remained enigmatic.
View Article and Find Full Text PDFBackground: There is a paucity of information around whether hospital length of stay and readmission rates differ based upon hospital type for adolescents and young adults (AYA) with complex chronic diseases (CCDs).
Objective: To measure the association between hospital type and readmission rates and index admission LOS among AYA with CCDs.
Methods: We performed a retrospective cross-sectional study of 2017 Healthcare Cost and Utilization Project State Inpatient Databases, including patients 12-25 years old with cystic fibrosis (CF), sickle cell disease (SCD), spina bifida (SB), inflammatory bowel disease (IBD), and diabetes mellitus (DM).
Article Synopsis
- * Researchers examined 172 cases and found that 58% had a positive urine culture, with most infections caused by Escherichia coli, yet only 17% of the prescribed antibiotic regimens were appropriate.
- * The results highlighted widespread inappropriate use of broad-spectrum antibiotics, particularly third cephalosporins, and indicated a need for better treatment protocols to avoid unnecessary prescriptions and prolonged treatments.