Publications by authors named "R Terranova"
The magnitude of benefit of Mediterranean diet in cancer prevention and mortality in older adults is still unclear, therefore we conducted a systematic review and meta-analysis. Outcomes considered were cancer incidence and cancer mortality. In studies evaluating cancer incidence as a time-to-event endpoint and adherence as quantiles, HR was 0.
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- * The research involved 230 patients, analyzing their EEG recordings to determine a power law exponent (β) that reflects brain connectivity and activity patterns.
- * Results showed that tauopathies had lower β values compared to α-synucleinopathies, suggesting that β could serve as a potential biomarker for distinguishing between these two types of neurodegenerative diseases.
Parkinson's Disease (PD) body-first subtype is characterized by prodromal autonomic symptoms and REM sleep behavior disorder (RBD), symmetric dopaminergic degeneration, and increased risk of dementia. On the other hand, the PD brain-first subtype has fewer non-motor symptoms and a milder motor phenotype. The temporal relationship between RBD onset and motor symptoms onset may differentiate these two subtypes.
View Article and Find Full Text PDFIntroduction: Type 1 (T1D) and type 2 diabetes (T2D) are associated with an elevated incidence of infectious diseases and a higher risk of infections-related hospitalization and death. In this study, we delineated the "vaccinome" landscape obtained with a large immunization schedule offered by the Regional Government of Lombardy in a cohort of 618,396 patients with diabetes (T1D and T2D).
Methods: Between September 2021 and September 2022, immunization coverage for influenza, meningococcus, pneumococcus, and herpes zoster was obtained from the public computerized registry of the healthcare system of Lombardy Region (Italy) in 618,396 patients with diabetes and in 9,534,087 subjects without diabetes.
Article Synopsis
- - Sickle cell disease (SCD) is a serious inherited condition caused by a mutation in the β-hemoglobin gene, and increasing fetal hemoglobin (HbF) levels can help reduce complications.
- - Researchers discovered two small molecules, dWIZ-1 and dWIZ-2, that act as molecular glue degraders to induce HbF by targeting a previously unrecognized repressor, the WIZ transcription factor.
- - These compounds effectively triggered HbF production in animal models, suggesting that targeting WIZ for degradation offers a promising and accessible new treatment approach for SCD.