Publications by authors named "R Taurines"
Article Synopsis
- Aripiprazole, a medication approved for severe mental disorders, is often prescribed off-label to children and adolescents, yet there are no established therapeutic serum level reference ranges for this population.
- A study aimed to investigate the relationship between aripiprazole dosage and serum concentrations in youth, identifying factors like sex, age, and weight that might influence these levels.
- The findings suggested a strong correlation between daily dosage and serum concentration, leading to a preliminary reference range for treating pediatric patients, which indicated potentially better outcomes and fewer side effects when using interquartile ranges for dose determination.
Article Synopsis
- A study conducted from November 2020 to June 2023 assessed the performance of SARS-CoV-2 rapid antigen tests (RDTs) compared to standard RT-qPCR testing among a large group of patients and staff in a hospital setting.
- The analysis of nearly 78,800 paired results revealed that RDTs had a sensitivity of 34.5% and a specificity of 99.6%, with sensitivity decreasing as fewer symptomatic infections occurred over the course of the pandemic.
- The findings suggest that RDTs are still effective for diagnosing COVID-19 in symptomatic patients and could be useful for identifying other respiratory infections in the future, despite their declining sensitivity linked to vaccination and the spread of the Omicron variant
Introduction: Challenging behaviour (CB) is a common issue among children with autism spectrum disorder or intellectual and developmental disability. Mental health applications are low-threshold cost-effective tools to address the lack of resources for caregivers. This pre-post study evaluated the feasibility and preliminary effectiveness of the smartphone app using algorithm-based behaviour analysis to identify causes of CB and provide individualized practical guidance to manage and prevent CB.
View Article and Find Full Text PDFIntroduction: Fluvoxamine is used in children and adolescents ('youths') for treating obsessive compulsive disorder (OCD) but also off-label for depressive and anxiety disorders. This study aimed to investigate the relationship between fluvoxamine dose and serum concentrations, independent correlates of fluvoxamine concentrations, and a preliminary therapeutic reference range (TRR) for youths with OCD and treatment response.
Methods: Multicenter naturalistic data of a therapeutic drug monitoring service, as well as prospective data of the 'TDM Vigil study' (EudraCT 2013-004881-33), were analyzed.
[Legal, clinical and structural aspects of modern intensive care for children and adolescents with mental disorders].
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
April 2024
Recent years have seen a continuous rise in the proportion of emergency contacts across all mental health-related care structures for children and adolescents. Treatment in a protective intensive care unit constitutes an essential element of care and primarily serves the immediate protection of children and adolescents during mental health crises. Protective intensive care is subject to strict legal requirements.
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