Publications by authors named "R Tatevossian"
Article Synopsis
- PeCan-Seq is a deep sequencing method developed to analyze circulating tumor DNA (ctDNA) in children with various cancers, particularly leukemias.
- The study found that ctDNA was detectable in nearly all children with hematologic malignancies, identifying 97% of expected tumor variants, while it was less effective for solid tumors and brain cancers.
- PeCan-Seq offers a non-invasive way to monitor disease progression and detect mutations, making it a valuable tool for understanding childhood cancers.
As part of the advancement in therapeutic decision-making for brain tumor patients at St. Jude Children's Research Hospital (SJCRH), we developed three robust classifiers, a deep learning neural network (NN), k-nearest neighbor (kNN), and random forest (RF), trained on a reference series DNA-methylation profiles to classify central nervous system (CNS) tumor types. The models' performance was rigorously validated against 2054 samples from two independent cohorts.
View Article and Find Full Text PDFBackground: Survival data for recurrent pediatric atypical teratoid rhabdoid tumor (ATRT) and its association to molecular groups are extremely limited.
Methods: Single-institution retrospective study of 64 children less than 21 years old with recurrent or treatment-refractory (progressive disease [PD]) ATRT treated at St. Jude Hospital from January 2000 to December 2020.
Article Synopsis
- Neuroblastoma is a type of cancer that affects kids and comes from certain developing nerve cells, and it can be really complicated with different types of cells in each tumor.
- Researchers studied 55 tumors from kids with neuroblastoma using advanced techniques to learn more about how these cancer cells work and act in the body.
- They discovered that the tumors have different groups of cells that can affect how serious the cancer is and how well kids can respond to treatment, and all their findings are shared online for other scientists to use.