Publications by authors named "R Tardanico"
Background: We compared protection of mycophenolate mofetil (MMF) and azathioprine (AZA) against acute cellular rejection (ACR) and chronic allograft nephropathy (CAN) in kidney transplant recipients on steroid-free, low-dose cyclosporine (CsA) microemulsion maintenance immunosuppression.
Methods And Findings: ATHENA, a pragmatic, prospective, multicenter trial conducted by 6 Italian transplant centers, compared the outcomes of 233 consenting recipients of a first deceased donor kidney transplant induced with low-dose thymoglobulin and basiliximab and randomized to MMF (750 mg twice/day, n = 119) or AZA (75 to 125 mg/day, n = 114) added-on maintenance low-dose CsA microemulsion and 1-week steroid. In patients without acute clinical or subclinical rejections, CsA dose was progressively halved.
Urothelial bladder cancer (UBC) are classified into luminal and basal subtypes showing distinct molecular features and clinical behaviour. Recent in silico data have proposed the activation on the Signal Transducer and Activator of Transcription 3 (STAT3) as relevant transcription factor in UBC. To answer this question, we have combined the retrospective analysis of clinical samples, functional assays on cell lines, interrogation of public UBC datasets and a murine model of basal-type UBC.
View Article and Find Full Text PDFBackground/aim: Clear cell renal cell carcinoma (ccRCC) shows variable chromosomal abnormalities. The aim of this study was to assess the prognostic role of ccRCC chromosomal abnormalities in a single-center cohort with an extended follow-up.
Materials And Methods: A systematic cytogenetic analysis was performed in 283 consecutive surgically-treated patients for renal masses between 1997 and 2002.
Article Synopsis
- The VALIGA study analyzed the use of the Oxford Classification for immunoglobulin A nephropathy (IgAN) in 1147 patients across 13 European countries, focusing on biopsy scoring and its impact on treatment decisions.
- The findings revealed that local pathologists tended to report more lesions than central pathologists, and variability in scoring was noted, particularly for mesangial hypercellularity and endocapillary hypercellularity.
- Ultimately, the study highlighted discrepancies in pathology assessments affecting treatment choices and clinical outcomes, suggesting that central reviews could offer more reliable evaluations for certain lesions.