Publications by authors named "R Tam"
Background: Cardiovascular disease remains the leading cause of mortality worldwide. Cardiac fibrosis impacts the underlying pathophysiology of many cardiovascular diseases by altering structural integrity and impairing electrical conduction. Identifying cardiac fibrosis is essential for the prognosis and management of cardiovascular disease; however, current diagnostic methods face challenges due to invasiveness, cost, and inaccessibility.
View Article and Find Full Text PDFPurpose: To evaluate linrodostat mesylate, a selective, oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, combined with nivolumab ± ipilimumab in advanced solid tumors and hematologic malignancies.
Patients And Methods: In this phase 1/2 study, patients received once-daily (QD) linrodostat (part 1 [escalation], 25-400 mg; part 2 [expansion], 100 or 200 mg) plus nivolumab (480 mg every [Q] 4 weeks [W] or 240 mg Q2W) or triplet therapy (part 3, linrodostat 20-100 mg QD; nivolumab 360 mg Q3W or 480 mg Q4W; ipilimumab 1 mg/kg Q6W or Q8W). Endpoints included safety and efficacy (co-primary; parts 2, 3), pharmacokinetics, pharmacodynamics, biomarkers, and efficacy (part 1).
Article Synopsis
- Alzheimer's disease is associated with impaired proteostasis, and enhancing it might help delay cognitive decline.
- KPT-330 (Selinexor), an XPO1 inhibitor, shows promise in improving proteostasis and enhancing autophagy in neurons, leading to better memory in Alzheimer's models.
- While KPT-330 increased overall amyloid deposition in the brain, it also resulted in lower levels of amyloid in specific areas like the thalamus, indicating that its effects on proteostasis and amyloid formation are region-specific.
Article Synopsis
- Cancer-related cognitive decline is common among breast cancer survivors, and the study explores how physical activity may influence this relationship while considering cancer treatments.
- The study involved 253 breast cancer survivors who completed cognitive tests and physical activity monitoring to examine the links between exercise and cognitive abilities.
- Results indicated that self-reported cognitive ability improved with greater physical activity, but objective cognition measurements showed no significant association; time since diagnosis was also linked to processing speed.
is the causal agent of myrtle rust in over 480 species within the family Myrtaceae. Lineages of are structured by their hosts in the native range, and some have success in infecting newly encountered hosts. For example, the pandemic biotype has spread beyond South America, and proliferation of other lineages is an additional risk to biodiversity and industries.
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