Publications by authors named "R Tagore"
Article Synopsis
- - Scrub typhus, common in tropical areas, can cause a variety of symptoms ranging from mild to severe, including respiratory and neurological issues, as seen in a rare case of a 34-year-old male experiencing high fever and muscle pain.
- - Despite initial treatment with antipyretics and oral antibiotics, the patient's condition worsened, leading to blurred vision, prompting further investigation that confirmed a diagnosis of scrub typhus with opsoclonus.
- - The patient improved significantly after receiving doxycycline, highlighting the importance of considering unusual infections in patients with neurological symptoms for timely and effective treatment.
RNA interference (RNAi) is a process in which small RNA molecules (such as small interfering RNAs or siRNAs) bind to specific messenger RNAs (mRNAs), leading to its degradation and inhibition of protein synthesis. Our studies have shown that RNAi can effectively silence genes involved in the replication of the Chikungunya virus (CHIKV) in cells. However, these investigations were performed only in laboratory settings and have yet to be tested in human clinical trials.
View Article and Find Full Text PDFIntroduction: Several non-pharmaceutical infection control measures have been implemented at community-based hemodialysis centers to reduce the risk of Coronavirus Disease of 2019 (COVID-19) transmission, caused by the SARS-CoV-2 virus. However, there have been concerns that such measures may disrupt the routine and timely care required by patients, with adverse effects on their health outcomes. This cross-sectional study aims to determine the unintended consequences of COVID-19 infection control measures on hemodialysis patients.
View Article and Find Full Text PDFArticle Synopsis
- * This study evaluated the effectiveness of the Brandwein-Gensler risk model, alongside factors like lympho-vascular invasion (LVI), depth of invasion (DOI), and lymph node metastases, in predicting LRR in early stage OSCC patients who underwent surgical treatment.
- * Out of 207 patients studied, LRR occurred in over half (54.6%), with significant risk factors for recurrence identified, emphasizing the need for careful monitoring and
Article Synopsis
- Chikungunya fever, caused by the chikungunya virus (CHIKV) transmitted by mosquitoes, is a significant public health issue with no available vaccines or antiviral treatments.
- Researchers propose using small interfering RNA (siRNA) to silence the virus's structural and non-structural genes as a potential antiviral treatment, which can be enhanced by effective delivery systems.
- The study demonstrates that carbonated metal-organic frameworks (specifically ZIF-C) can efficiently deliver siRNAs targeting CHIKV genes, resulting in notably decreased viral replication and infectivity in infected cells compared to standard free siRNA delivery.