[Early cellular immune exhaustion in patients with Epstein-Barr virus activation following haploidentical hematopoietic stem cell transplantation].

This study aimed to investigate the association between early immune reconstitution and Epstein-Barr virus (EBV) reactivation by analyzing changes in natural killer (NK), B, and T cells and their functional status in the peripheral blood during the early post-transplant period. This study included 23 patients who underwent haplo-hematopoietic stem cell transplantation (HSCT). The immune reconstitution of NK cells, T cells, and B cells as well as the expression levels of NK and T cell exhaustion markers (PD-1, TIM-3, and CTLA-4) and cytotoxic function at 1, 2, and 3 months post-transplantation were compared between patients with EBV activation (EBV+ group) and those without activation (EBV- group) post- transplantation.

Electronic and vacancy engineering of ruthenium doped hollow-structured NiO/CoO nanoreactors for low-barrier electrochemical urea-assisted energy-saving hydrogen production.

Discovering a valid approach to achieve a novel and efficient water splitting catalyst is essential for the development of hydrogen energy technology. Herein, unique hollow-structured ruthenium (Ru)-doped nickel-cobalt oxide (Ru-NiO/CoO/NF) nanocube arrays are fabricated as high-efficiency bifunctional electrocatalysts for hydrogen evolution reaction (HER)/urea oxidation reaction (UOR) through combined electronic and vacancy engineering. The structural characterization and experimental results indicate that the doping of Ru can not only effectively modulate the electronic structure of Ru-NiO/CoO/NF, but also increase the content of oxygen vacancies in the structure of Ru-NiO/CoO/NF to stabilize the existence of oxygen vacancies during the catalytic process.

New Contributions on Species Diversity of Genus and s.l. in China.

Southwest China is extremely rich in fungal resources, and a large number of new taxa have been discovered in recent years. In the present study, we examined 26 specimens of the genera and sensu lato, most of which were obtained in Yunnan Province. Through ITS-nrLSU- phylogenetic analysis, combined with morphological studies and geographic analyses, five new species were described, viz.

An explainable predictive model for anxiety symptoms risk among Chinese older adults with abdominal obesity using a machine learning and SHapley Additive exPlanations approach.

Background: Early detection of anxiety symptoms can support early intervention and may help reduce the burden of disease in later life in the elderly with abdominal obesity, thereby increasing the chances of healthy aging. The objective of this research is to formulate and validate a predictive model that forecasts the probability of developing anxiety symptoms in elderly Chinese individuals with abdominal obesity.

Method: This research's model development and internal validation encompassed 2,427 participants from the 2017-2018 Study of the Chinese Longitudinal Healthy Longevity Survey (CLHLS).

Pharmacokinetics and metabolism of ketoconazole after single ocular instillation in Sprague-Dawley rats.

Background And Purpose: Ketoconazole is limited to its conditioned oral use due to hepatic toxicity. Its ocular eye drop administration may be an option for mycotic keratitis treatment. Therefore, it is necessary to explore its pharmacokinetic and metabolic profile via topical ocular administration.