Biofortification: Future Challenges for a Newly Emerging Technology to Improve Nutrition Security Sustainably.

Biofortification was coined as a term to define a plant breeding strategy to increase the micronutrient content of staple food crops to reduce the burden of micronutrient deficiencies in low- and middle-income countries. In 2003, the HarvestPlus program, based in the centers comprising the Consultative Group on International Agricultural Research, was initiated to implement the biofortification strategy. This article discusses what has been achieved, what has been learned, and the key challenges to embed biofortification in food systems and to expand its impact.

Clinical evaluation of CoolSeal - a new, safe, and fast vessel sealing device in total thyroidectomy.

CoolSeal is a new vessel sealing system for dissection and hemostasis during surgery. No clinical studies have investigated safety, advantages or disadvantages regarding the use of this device. The aim of the present study was to investigate the safety of CoolSeal and compare it with conventional ligation technique or LigaSure during the total thyroidectomy.

Increased risk of chronic kidney disease after total thyroidectomy: A nationwide matched cohort study.

Background: Development of hypoparathyroidism (hypoPT) after total thyroidectomy (TT) may increase the risk of kidney-related morbidity. We aimed to examine the risk of hypoPT and chronic kidney disease (CKD) in patients undergoing TT in Denmark over a 20-year period.

Materials And Methods: Using population-based registries, we identified all Danish individuals with TT between January 1998 and December 2017.

Hypoparathyroidism and mortality after total thyroidectomy: A nationwide matched cohort study.

Objective: Total thyroidectomy (TT) carries a risk of hypoparathyroidism (hypoPT). Recently, hypoPT has been associated with higher overall mortality rates. We aimed to evaluate the frequency of hypoPT and mortality in patients undergoing TT in Denmark covering 20 years.

CRISPR-mediated promoter editing of a -regulatory element of increases Zn uptake/translocation and plant yield in rice.

Developing nutritious rice with a higher yield is one approach to alleviating the problem of micronutrient deficiency in developing countries, especially human malnutrition involving zinc and iron (Fe) deficiency, and achieving better adoption. The transport of micronutrients such as Fe and Zn is mainly regulated via the nicotianamine synthase () gene family, whereas yield is a complex trait that involves multiple loci. Genome editing via CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9, focusing on the promoter, particularly the deletion of the -regulatory element at position -933, was conducted for an enhanced accumulation of Zn in the grain and per plant.