N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.

Recent studies have demonstrated that selective 5-HT(1F) receptor agonists inhibit neurogenic dural inflammation, a model of migraine headache, indicating that these compounds may be effective therapies for the treatment of migraine pain. This communication describes the synthesis and discovery of a novel compound, N-[3-(2-(dimethylamino)ethyl)-2-methyl-1H-indol-5-yl]-4-fluorobenzamide (4), which possesses high binding affinity and selectivity at the 5-HT(1F) receptor relative to more than 40 other serotonergic and nonserotonergic receptors examined.

Mechanical treatment of plantar fasciitis. A prospective study.

A randomized, prospective study was conducted to compare the effectiveness of three individual mechanical modalities in the treatment of plantar fasciitis. Two hundred fifty-five subjects were randomly assigned to one of three treatment groups: custom-made orthoses, over-the-counter arch supports, or tension night splints. Subjects were treated for 3 months, with follow-up visits at 2, 6, and 12 weeks.

How effective is manual palpation in detecting subtle temperature differences?

In the management of diabetic, neuropathic sequelae, namely ulceration and Charcot's arthropathy, appropriate quantification of inflammation is critically important in predicting future events and charting current progress. This article evaluates the ability of the physician to quantify subtle differences in temperature through manual palpation. The "laying on of hands" in a clinical setting is a necessary, crucial component of the doctor-patient relationship; however, our data suggest that manual palpation, even in a controlled environment, may not be an objective means to assess temperature, a cardinal sign of inflammation.

Value of white blood cell count with differential in the acute diabetic foot infection.

The authors reviewed the admission leukocyte indices of 338 consecutive admissions (203 males, 135 females, mean age of 60.2 +/- 12.9 years) with a primary diagnosis of diabetic foot infection in a multicenter retrospective study.