Publications by authors named "R T M Boudreau"
We and others previously found that a misannotated long noncoding RNA encodes for a conserved mitochondrial transmembrane microprotein named Mitoregulin (Mtln). Beyond an established role for Mtln in lipid metabolism, Mtln has been shown to broadly influence mitochondria, boosting respiratory efficiency and Ca retention capacity, while lowering ROS, yet the underlying mechanisms remain unresolved. Prior studies have identified possible Mtln protein interaction partners; however, a lack of consensus persists, and no claims have been made about Mtln's structure.
View Article and Find Full Text PDFBackground: Canada is the only country with universal health care lacking universal pharmaceutical care (pharmacare). Currently, a minority portion of the population has drug coverage. Furthermore, there may be discordance between provincial plans of medications that are covered.
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- The study aimed to compare the effectiveness of enhanced MOSES 2.0 technology against the older MOSES 1.0 technology in performing holmium laser enucleation of the prostate (HoLEP) for benign prostatic hyperplasia (BPH).
- A total of 196 patients were examined, with no significant differences in preoperative characteristics; however, the MOSES 2.0 group showed shorter enucleation and hemostasis times and used less laser energy.
- The findings suggest that HoLEP with MOSES 2.0 is a safe and effective treatment for BPH, with improved efficiency but similar postoperative outcomes compared to MOSES 1.0.
The World Health Organization has identified antibiotic resistance as one of the three greatest threats to human health. The need for antibiotics is a pressing matter that requires immediate attention. Here, computer-aided drug design is used to develop a structurally unique antibiotic family targeting holo-acyl carrier protein synthase (AcpS).
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- One third of organ donors experience catastrophic brain injury (CBI), but there’s no standardized management for traumatic CBI among trauma centers, leading to variability in practices.
- A multicenter trial involving 33 trauma centers analyzed 790 CBI patients to investigate whether institutions with CBI guidelines had higher organ donation rates.
- While centers with CBI guidelines showed greater use of certain treatments, the presence of guidelines did not significantly increase organ donation rates; however, hormone therapies were linked to a higher likelihood of donation.