Publications by authors named "R T Kirkland"

The escalating stress epidemic in modern society has raised concerns about its impact on physical and mental health, prompting the need for effective interventions. Yoga, a multifaceted mind-body practice, has gained recognition for its potential in mitigating perceived stress. Our meta-analysis aimed to estimate yoga's impact on lowering perceived stress as measured by the Perceived Stress Scale.

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Article Synopsis
  • The gastrointestinal (GI) microbiota significantly affects the host's immune response, metabolism, and various health conditions, with diet being the primary factor influencing its composition.
  • High-fat (HF) diets can cause dysbiosis, leading to negative changes in gut-brain signaling that may contribute to overeating and obesity.
  • In a study, transferring lean microbiota to obese rats on HF diets improved gut-brain communication, reduced calorie intake, and prevented further weight gain, suggesting that enhancing microbiota can help restore normal eating behaviors and metabolic health.
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Chronic consumption of high fat (HF) diets has been shown to increase meal size and meal frequency in rodents, resulting in overeating. Reducing meal frequency and establishing periods of fasting, independently of caloric intake, may improve obesity-associated metabolic disorders. Additionally, diet-driven changes in microbiota composition have been shown to play a critical role in the development and maintenance of metabolic disorders.

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Background: The collection of microorganisms, mainly bacteria, which live in the gastrointestinal (GI) tract are collectible known as the gut microbiota. GI bacteria play an active role in regulation of the host's immune system and metabolism, as well as certain pathophysiological processes. Diet is the main factor modulating GI microbiota composition and recent studies have shown that high fat (HF) diets induce detrimental changes, known as dysbiosis, in the GI bacterial makeup.

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Over the last 20 years, the understanding and natural history of Rett syndrome has advanced, but to date no cure has emerged, with multidisciplinary management being symptomatic and supportive. This study provides a comprehensive review of the clinical features, comorbidities and multidisciplinary management of a well-characterized cohort of females with classical Rett syndrome. We aim to improve awareness and understanding of Rett syndrome amongst pediatricians, pediatric subspecialists and allied health professionals to enable early diagnosis and a streamlined enrolment approach for future clinical trials.

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