Publications by authors named "R T Kevorkian"
Hypothermia in combination with infection presents a complex challenge in clinical and battlefield medicine. Multifaceted physiological and immunological consequences of hypothermia drastically change the risk, progression, and treatment of a concomitant infection. Managing hypothermia and infection in extreme cold settings is particularly relevant in an era with increased risk of military operations in Polar climates.
View Article and Find Full Text PDFIntroduction: Molecular hydrogen is produced by the fermentation of organic matter and consumed by organisms including hydrogenotrophic methanogens and sulfate reducers in anoxic marine sediment. The thermodynamic feasibility of these metabolisms depends strongly on organic matter reactivity and hydrogen concentrations; low organic matter reactivity and high hydrogen concentrations can inhibit fermentation so when organic matter is poor, fermenters might form syntrophies with methanogens and/or sulfate reducers who alleviate thermodynamic stress by keeping hydrogen concentrations low and tightly controlled. However, it is unclear how these metabolisms effect porewater hydrogen concentrations in natural marine sediments of different organic matter reactivities.
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- The study investigates how the bacteria serovar Typhimurium reacts to different diets (fibrous vs. high-fat) over time in mice, focusing on its metabolic responses and implications for antibiotic resistance.
- Findings indicate that mice on a high-fat diet showed increased inflammation, affecting gene expression related to respiration and infection phases (early, peak, late), highlighting the bacteria's adaptability.
- The research suggests that understanding these dietary influences on serovar Typhimurium could lead to new therapeutic strategies to combat infections, especially amid rising antibiotic resistance.
Chronic Chagas cardiomyopathy (CCC) has unique pathogenic and clinical features with worse prognosis than other causes of heart failure (HF), despite the fact that patients with CCC are often younger and have fewer comorbidities. Patients with CCC were not adequately represented in any of the landmark HF studies that support current treatment guidelines. PARACHUTE-HF (Prevention And Reduction of Adverse outcomes in Chagasic Heart failUre Trial Evaluation) is an active-controlled, randomized, phase IV trial designed to evaluate the effect of sacubitril/valsartan 200 mg twice daily vs enalapril 10 mg twice daily added to standard of care treatment for HF.
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- The research investigates how the serovar Typhimurium bacterium adapts its metabolic response to different diets, specifically fibrous versus high-fat, over time, which is crucial for developing new treatments for infections amid increasing antibiotic resistance.
- A multi-omics approach was used in mice, revealing that the high-fat diet led to increased inflammation and distinct phases of infection based on gene expression, including genes linked to how the bacteria enter host cells.
- The findings underscore the importance of understanding pathogen responses to dietary changes, suggesting potential targets for therapies to combat infections linked to shifts toward high-fat, low-fiber diets.