Study Objectives: Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep macro-architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium (SDC).
View Article and Find Full Text PDFUnlabelled: Neurodegenerative disorders, including Alzheimer's disease and AD-related dementias (AD/ADRD), pose significant challenges to health care systems globally, particularly in Africa. With the advances in medical technology and research capabilities, especially in next-generation sequencing and imaging, vast amounts of data have been generated from AD/ADRD research. Given that the greatest increase in AD/ADRD prevalence is expected to occur in Africa, it is critical to establish comprehensive bioinformatics training programs to help African scientists leverage existing data and collect additional information to untangle AD/ADRD heterogeneity in African populations.
View Article and Find Full Text PDFThis work reports the synthesis and beta particle excited thermoluminescence (TL) characteristics of NaF and NaF:Tm phosphors synthesized via wet precipitation. The samples were subjected to thermal annealing at 750 °C for 5, 10, and 24 h in an air atmosphere. A sensitization effect is observed in repeated irradiation-TL readout cycles.
View Article and Find Full Text PDFIntroduction: We investigated whether depression modified the associations between sleep duration and cognitive performance.
Methods: Multivariable linear regression models examined the associations between sleep duration and cognition in 1,853 dementia- and stroke-free participants from the Framingham Heart Study. Participants were categorized in four groups: no depressive symptoms, no antidepressants; depressive symptoms without antidepressants use; antidepressant use without depressive symptoms; both depressive symptoms and antidepressant use.
The non-thermoluminescence afterglow-based dosimetry performance of self-agglomerating pellet-shaped CaSO:Dy phosphors synthesized through a low-cost, environmentally friendly method is first reported. Thermoluminescence (TL) and afterglow (AG) were analyzed in samples exposed to beta particle irradiation in the dose range from 0.06 to 8.
View Article and Find Full Text PDF