Proteomic characterization and comparison of the infective and adult life stage secretomes from Necator americanus and Ancylostoma ceylanicum.

More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management approaches are limited by modest drug efficacy, the costs associated with frequent mass drug administration campaigns, and the risk of reinfection and burgeoning drug resistance.

Magnetic Resonance Cholangiopancreatography for Cholangiopancreatic Duct Imaging in Dogs.

Ultrasonography is often used to diagnose biliary diseases in dogs; however, it is difficult to delineate the entire bile and pancreatic ducts. Various imaging techniques for bile and pancreatic ducts have been attempted to overcome this problem. Magnetic resonance cholangiopancreatography (MRCP) is often used to evaluate the bile and pancreatic ducts in humans with obstructive jaundice, but very few reports exist on its usage in dogs.

Whole-Cell Thermal Sensor for the Detection of -Infected Erythrocytes: Imprinted Polymers as Synthetic Receptors for the Detection of Malaria.

Malaria is a major public healthcare concern worldwide, representing a leading cause of death in specific regions. The gold standard for diagnosis is microscopic analysis, but this requires a laboratory setting, trained staff, and infrastructure and is therefore typically slow and dependent on the experience of the technician. This study introduces, for the first time, a biomimetic sensing platform for the direct detection of the disease.

Parasite infections: how inflammation alters brain function.

Parasitic infections can profoundly impact brain function through inflammation within the central nervous system (CNS). Once viewed as an immune-privileged site, the CNS is now recognized as vulnerable to immune disruptions from both local and systemic infections. Recent studies reveal that certain parasites, such as Toxoplasma gondii and Plasmodium falciparum, can invade the CNS or influence it indirectly by triggering neuroinflammation.

Prognostic significance of body mass index in patients with metastatic renal cell carcinoma receiving first-line therapies.

Objectives: Higher body mass index (BMI) is reportedly associated with improved prognosis of patients with various cancers. However, it is unclear whether this phenomenon, also known as the obesity paradox, applies to metastatic renal cell carcinoma (mRCC). We aimed to determine the prognostic significance of BMI in patients with mRCC receiving first-line therapies.