We previously demonstrated that a prime-boost regime with an infectious bronchitis virus (IBV) Massachusetts (Mass)-type vaccine and recombinant LaSota virus (rLS) coexpressing IBV Arkansas (Ark)-type trimeric spike ectodomain (Se) and granulocyte macrophage colony stimulating factor (GMCSF) enhances heterologous protection against virulent Ark challenge. This study evaluates protection against Ark-type challenge conferred by administering the rLS/ArkSe.GMCSF and the attenuated Mass viruses mixed in the same vial as a combined vaccine.
View Article and Find Full Text PDFUnderstanding gene expression changes in chicks after vaccination against Newcastle Disease (ND) can reveal vaccine biomarkers. There are limited data on chicks' early immune response after ND vaccination. Two trials focused on this knowledge gap.
View Article and Find Full Text PDFThis contribution offers the author's personal experience with a project that took place 25 years ago in Latin America. This was about Second Order Auditing in Colombia during the second part of the 1990s. This project was carried out at the Country's National Auditing Office (CGR), and was an application of the (VSM) and the Viplan Methodology to a National Context.
View Article and Find Full Text PDFThis contribution offers reflections about Chilean Cybersyn, 50 years ago. In recent years, Cybersyn, has received significant attention. It was the brainchild of Stafford Beer, who conceived it to support the transformation of the Chilean economy from its bureaucratic history to hopefully create a vibrant and modern society, driven by cybernetic tools.
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