Publications by authors named "R Szalat"
Article Synopsis
- Kidney light chain (AL) amyloidosis can lead to serious health issues including the need for kidney replacement therapy and increased mortality risk, with better outcomes linked to significant reductions in proteinuria after treatment.
- This study aimed to confirm how different levels of kidney response to treatment relate to patient survival, using data from 732 patients over several years.
- Results showed that deeper kidney responses within 6 months of treatment initiation were associated with significantly lower chances of needing kidney replacement therapy after 5 years.
The natural history of multiple myeloma is characterized by its localization to the bone marrow and its interaction with bone marrow stromal cells. The bone marrow stromal cells provide growth and survival signals, thereby promoting the development of drug resistance. Here, we show that the interaction between bone marrow stromal cells and myeloma cells (using human cell lines) induces chromatin remodeling of cis-regulatory elements and is associated with changes in the expression of genes involved in the cell migration and cytokine signaling.
View Article and Find Full Text PDFMultiple myeloma (MM) is a hematologic malignancy characterized by clonal proliferation of plasma cells. MM is a heterogeneous disease, featured by various molecular subtypes with different outcomes. With the advent of very efficient therapies including monoclonal antibodies, bispecific T-cell engagers and chimeric antigen receptor T cells (CAR T cells), most MM patients now have a prolonged survival.
View Article and Find Full Text PDFBackground: Obesity is an established risk factor for multiple myeloma (MM). Relatively few prior studies, however, have evaluated associations in Black populations.
Methods: Among 55,276 participants in the Black Women's Health Study, a prospective U.