The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19.

Despite the tremendous advancements in the knowledge of the pathophysiology and clinical aspects of SARS-CoV-2 infection, still many issues remain unanswered, especially in the long-term effects. Mounting evidence suggests that pulmonary fibrosis (PF) is one of the most severe complications associated with COVID-19. Therefore, understanding the molecular mechanisms behind its development is helpful to develop successful therapeutic strategies.

The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities.

Glycolytic metabolism generates energy and intermediates for biomass production. Tumor-associated glycolysis is upregulated compared to normal tissues in response to tumor cell-autonomous or non-autonomous stimuli. The consequences of this upregulation are twofold.

Circular economy and sustainable development in the tourism sector - An overview of the truly-effective strategies and related benefits.

Circular Economy (CE) is considered a possible solution to mitigate the environmental externalities of the tourism industry, with a view to more sustainable tourism by reducing environmental, social, and economic burdens in an integrated holistic approach. Moreover, the role of CE in tourism is highlighted by the possibility of achieving all sustainable development goals (SDGs) directly and indirectly using the links that connect SDG 12 with the others. From this point of view, this literature review was aimed at discussing the key strategies of CE applied to the tourism industry, focussing on the widespread problems of single-use plastic, excess food, and water consumption.

Correction: Zwergel et al. Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation. 2020, , 447.

In the original publication [...

Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype.

Infectious peritonitis is a leading cause of peritoneal functional impairment and a primary factor for therapy discontinuation in peritoneal dialysis (PD) patients. Although bacterial infections are a common cause of peritonitis episodes, emerging evidence suggests a role for viral pathogens. Toll-like receptors (TLRs) specifically recognize conserved pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and fungi, thereby orchestrating the ensuing inflammatory/immune responses.