Publications by authors named "R Stephen McCain"

Locally sustained release antimicrobials such as silver nanoparticles (AgNPs) might prove useful in combating local infections. Their elution has been investigated in Phosphate Buffered Saline (PBS) including from poloxamer 407 (P407). No information exists on possible interactions with proteins, nor have ultrafiltration (UF) probes been evaluated to measure Ag.

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Article Synopsis
  • - Muscle atrophy due to disuse, aging, or illness can lead to increased risks of injury and prolonged recovery, with macrophages playing a crucial role in muscle regeneration by releasing insulin-like growth factor 1 (IGF-1).
  • - Researchers encapsulated all-trans retinoic acid (ATRA) in microparticles to improve its bioavailability and promote IGF-1 release from macrophages, enhancing muscle cell formation and regeneration.
  • - The study shows that ATRA-PLG microparticles are effectively taken up by macrophages and can stimulate IGF-1 production, supporting further research on its potential use in muscle recovery treatments.
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The tricarboxylic acid (TCA) cycle metabolite fumarate nonenzymatically reacts with the amino acid cysteine to form S-(2-succino)cysteine (2SC), referred to as protein succination. The immunometabolite itaconate accumulates during lipopolysaccharide (LPS) stimulation of macrophages and microglia. Itaconate nonenzymatically reacts with cysteine residues to generate 2,3-dicarboxypropylcysteine (2,3-DCP), referred to as protein dicarboxypropylation.

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Objective: To compare the influence of fluid on carboplatin elution, and assess the feasibility of ultrafiltration (UF) probe sampling.

Sample: 20 samples of 5 mg carboplatin in 1.0 mL 30% poloxamer 407 eluting in Dulbecco's phosphate-buffered saline (DPBS) or canine plasma and 6 samples of UF probe sampling in 0.

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Cyanide represents a persistent threat for accidental or malicious misuse due to easy conversion into a toxic gas and access to large quantities through several industries. The high safety index of hydroxocobalamin is a cornerstone quality as a cyanide scavenger. Unfortunately, intravenous infusion of hydroxocobalamin limits the utility in a mass casualty setting.

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