[Hartnup disease (report of 2 cases in one family)].

Introduction: The Hartnup mutation affects the amino acid transport system of the intestine and kidney used by a large group of neutral amino acids (monoamino-monocarboxylic acids) resulting in a characteristic pattern of neutral aminoaciduria [2, 5, 6].

Methods And Patients: In this research clinical and neurological methods and a great number of laboratory tests were used. Patient 1.

Modification of the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase of hen brain.

This study was aimed to investigate the possibility of modifying the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase (NTE) of hen brain. This reaction on NTE occurs with a half-time of 7.4 min.

Endothelium-independent contractile and relaxant responses to histamine in the rabbit aorta and common carotid, mesenteric, renal, and femoral arteries.

1. The role of the vascular endothelium in the relaxant and contractile responses to histamine of the isolated rabbit aorta; common carotid, mesenteric, renal, and femoral arteries; as well as receptor types mediating these responses were analyzed. 2.

Interaction of phosphamidon with neuropathy target esterase and acetylcholinesterase of hen brain.

Phosphamidon (PSM) is an organophosphorus insecticide widely used in agriculture. This study was undertaken to examine the interaction of PSM with acetylcholinesterase (AChE) and neuropathy target esterase (NTE) of hen brain in vitro and in vivo. PSM was a potent inhibitor of AChE, with an I50 of 2.

Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF.

The mechanism of histamine-induced relaxation in the isolated rat common carotid artery was analysed. Histamine (3 x 10(-7)-10(-4) mol/l) caused a concentration-dependent relaxation of the artery. Indomethacin, a cyclo-oxygenase inhibitor, and diethylcarbamazine, a lipoxygenase inhibitor, did not affect the relaxant response of the artery to histamine.