Publications by authors named "R Steadman"
Epoxytiglianes are a novel class of diterpene esters. The prototype epoxytigliane, EBC-46 (tigilanol tiglate), is a potent anti-cancer agent in clinical development for local treatment of a range of human and animal tumors. EBC-46 also consistently promotes wound re-epithelialization at the treatment sites, mediated via activation of classical protein kinase C (PKC) isoforms.
View Article and Find Full Text PDFSimulation is underutilized as a tool to improve healthcare quality and safety despite many examples of its effectiveness to identify and remedy quality and safety problems, improve teamwork, and improve various measures of quality and safety that are important to healthcare organizations, eg, patient safety indicators. We urge quality and safety and simulation professionals to collaborate with their counterparts in their organizations to employ simulation in ways that improve the quality and safety of care of their patients. These collaborations could begin through initiating conversations among the quality and safety and simulation professionals, perhaps using this article as a prompt for discussion, identifying one area in need of quality and safety improvement for which simulation can be helpful, and beginning that work.
View Article and Find Full Text PDFSimulation is underutilized as a tool to improve healthcare quality and safety despite many examples of its effectiveness to identify and remedy quality and safety problems, improve teamwork, and improve various measures of quality and safety that are important to healthcare organizations, eg, patient safety indicators. We urge quality and safety and simulation professionals to collaborate with their counterparts in their organizations to employ simulation in ways that improve the quality and safety of care of their patients. These collaborations could begin through initiating conversations among the quality and safety and simulation professionals, perhaps using this article as a prompt for discussion, identifying one area in need of quality and safety improvement for which simulation can be helpful, and beginning that work.
View Article and Find Full Text PDFArticle Synopsis
- Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) are increasingly viewed as part of the same disease continuum, with Ischaemia Reperfusion Injury (IRI) being the leading cause of AKI, often linked to conditions like sepsis.
- The study demonstrated a rat model of kidney IRI, utilizing Ischaemic Preconditioning (IPC) to investigate its protective effects against AKI and renal fibrosis.
- Results showed that IPC significantly reduced renal fibrosis by 66% compared to IRI alone, highlighting a possible transitional point at 14 days when kidneys may either recover or progress to fibrosis, suggesting new targets for treatment.
Article Synopsis
- The guideline aims to create evidence-based recommendations for ICU clinicians treating adults with acute liver failure (ALF) or acute on chronic liver failure (ACLF).
- A panel of 27 experts conducted systematic reviews and categorized their findings into Population, Intervention, Comparison, and Outcomes (PICO) questions to guide clinical practice.
- The resulting 28 recommendations include five strong recommendations and 21 conditional ones, but many are based on low-quality evidence, highlighting areas that need further research.