Publications by authors named "R Stanzione"
Atrial natriuretic peptide (ANP) modulates stress-induced autophagy in endothelial cells.
Biochim Biophys Acta Mol Cell Res
January 2025
Atrial natriuretic peptide (ANP), a cardiac hormone involved in the regulation of water/sodium balance and blood pressure, is also secreted by endothelial cells, where it exerts protective effects in response to stress. Autophagy is an intracellular self-renewal process involved in the degradation of dysfunctional cytoplasmic elements. ANP was recently reported to act as an extracellular regulator of cardiac autophagy.
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- Scientists studied rats that are prone to strokes to understand how high salt diets affect their gut bacteria and stroke risk.
- They compared two types of rats: one that is more likely to get strokes (SHRSPs) and one that is less likely (SHRSRs) while they ate a special high-salt diet for a few weeks.
- The gut bacteria in the stroke-prone rats changed in a way that might increase their chances of having a stroke, showing that a bad diet could harm gut health and lead to serious problems.
Article Synopsis
- * Recent studies focus on autophagy, a cellular process, and its complex role in protecting or harming neurons during ischemic stroke, based on experiments with animal models.
- * Properly managing autophagy could be a potential way to prevent or lessen brain injury from strokes, highlighting the need for more research in this area.
Article Synopsis
- - Naringenin (NRG) is shown to counteract mitochondrial dysfunction, which is important in preventing cardiovascular diseases, by selectively inhibiting the FF-ATPase enzyme involved in ATP hydrolysis.
- - NRG interacts with FF-ATPase in a way that blocks energy transmission, particularly when calcium (Ca) ions are present, illustrating its preference for the enzyme activated by Ca over magnesium (Mg).
- - The study indicates that NRG helps protect against cell injury in cerebral endothelial cells, restoring cell viability and function after salt-induced damage, while also improving mitochondrial activity.
Abnormal expression of sphingolipid-metabolizing enzymes in the heart of spontaneously hypertensive rat models.
Biochim Biophys Acta Mol Cell Biol Lipids
January 2024
Sphingolipids exert important roles within the cardiovascular system and related diseases. Perturbed sphingolipid metabolism was previously reported in cerebral and renal tissues of spontaneously hypertensive rats (SHR). Specific defects related to the synthesis of sphingolipids and to the metabolism of Sphingosine-1-Phospahte (S1P) were exclusively identified in the stroke-prone (SHRSP) with the respect to the stroke-resistant (SHRSR) strain.
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