Publications by authors named "R Spoto"
Background: Optimal therapy following breast-conserving surgery in older adults with low-risk, early-stage breast cancer remains uncertain. The EUROPA trial aims to compare the effects of radiotherapy and endocrine therapy as single-modality treatments on health-related quality of life (HRQOL) and ipsilateral breast tumour recurrence (IBTR) outcomes in this population.
Methods: This non-inferiority, phase 3, randomised study was conducted at 18 academic hospitals across Italy (17 centres) and Slovenia (one centre).
Article Synopsis
- A study was conducted to assess current treatment practices for extensive-stage small-cell lung cancer (ES-SCLC) among Italian clinicians, especially regarding the use of radiation therapy.
- The survey involved 225 cancer care professionals, with 90 responding, mainly radiation oncologists with significant experience; the results highlighted a preference for combining chemotherapy with immunotherapy and the common use of prophylactic cranial irradiation (PCI).
- The findings revealed variability in treatment approaches for ES-SCLC, indicating a need for further clinical trials and improved multidisciplinary strategies for managing these patients.
Background: Stereotactic ablative radiotherapy (SABR) is emerging as a potential local treatment option for oligometastatic RCC. This study aims to evaluate the efficacy of SABR in patients with oligorecurrent RCC.
Methods: A total of 50 patients with histologically confirmed RCC underwent SABR for oligorecurrence between 2006 and 2022.
Few data are available on the role of SBRT re-irradiation for isolated recurrences. We designed a prospective phase I study to evaluate the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation, for peripheral lung lesions. RT was delivered with a dose escalation design from 30 Gy in five fractions up to 50 Gy in five fractions.
View Article and Find Full Text PDFBackground: Oligometastases in mediastinal nodes are increasingly prevalent, posing challenges for treatment with stereotactic body radiotherapy (SBRT) due to proximity to organs at risk (OARs). We report the results of a single prospective observational phase II trial on ablative SBRT for medically inoperable thoracic nodes metastases (NCT02970955).
Material And Methods: Since 2017, patients with < 3 nodal metastases were evaluated by the tumor board and included if deemed inoperable.