Development of a Tablet-Based Outpatient Care Application for People With Dementia: Interview and Workshop Study.

Background: Dementia management presents a significant challenge for individuals affected by dementia, as well as their families, caregivers, and health care providers. Digital applications may support those living with dementia; however only a few dementia-friendly applications exist.

Objective: This paper emphasizes the necessity of considering multiple perspectives to ensure the high-quality development of supportive health care applications.

Virtual tissue expression analysis.

Motivation: Bulk RNA expression data are widely accessible, whereas single-cell data are relatively scarce in comparison. However, single-cell data offer profound insights into the cellular composition of tissues and cell type-specific gene regulation, both of which remain hidden in bulk expression analysis.

Results: Here, we present tissueResolver, an algorithm designed to extract single-cell information from bulk data, enabling us to attribute expression changes to individual cell types.

Navigating Contract Negotiations.

Negotiating a first contract can be a stressful experience for soon-to-be early-career physicians. Most trainees do not have extensive experience with the contract negotiation process, and this unfamiliarity often breeds a lack of confidence and anxiety. However, understanding some key points and the general mechanics of a contract will help bridge any areas of uncertainty.

Correcting for Observation Bias in Cancer Progression Modeling.

Tumor progression is driven by the accumulation of genetic alterations, including both point mutations and copy number changes. Understanding the temporal sequence of these events is crucial for comprehending the disease but is not directly discernible from cross-sectional genomic data. Cancer progression models, including Mutual Hazard Networks (MHNs), aim to reconstruct the dynamics of tumor progression by learning the causal interactions between genetic events based on their co-occurrence patterns in cross-sectional data.

[What importance does outpatient care have for mobility in rural areas? Results from a GPS study among persons aged 75 and older].

Background: Out-of-home mobility, defined as active and passive movement through external environments, is a resource for autonomy, quality of life, and self-realization in older age. Various factors influence out-of-home mobility, primarily studied in urban settings. The study aims to examine associated factors in a study population aged 75 and above in rural areas.