Carbohydrate content of apolipoprotein B-48 from rat chylomicrons of varying density.

Monosaccharide composition was determined in apolipoprotein B-48 (apoB) of chylomicrons of rat mesenteric lymph. Chylomicrons were separated into three fractions based on density. Triglyceride and apolipoprotein content were determined in each.

Alterations of secretory pattern of intestinal lipoproteins by the benzoyl ester derivative of poloxalene surfactant (BEP).

Hydrophobic surfactant BEP was administered intraduodenally as part of lipid emulsion to rats with cannulated mesenteric lymphatic duct. The effect on the size and composition of intestinal triglyceride-rich lipoproteins (TRLp) was assessed by comparing the results with those obtained during infusion of the lipid emulsion alone. Administration of BEP decreased intestinal capacity to transport triglyceride and cholesterol in large TRLp, SF greater than 2000, and resulted in a significant reduction of total triglyceride in lymph.

Hydrophobic surfactant effects on aortic cholesterol accumulation and atherosclerosis in hypercholesterolemic rabbits.

Studies were performed in hypercholesterolemic rabbits to determine whether the hydrophobic surfactant, Poloxalene 2930 (Pol), is of benefit under these conditions. Lipoprotein analyses plus chemical and morphologic studies of the aorta were performed to evaluate the results. In one study, rabbits were made hypercholesterolemic by dietary means and then divided into two groups and given a cholesterol-free diet with one group additionally given Pol with treatment continued for 10 weeks.

Activity of some hydrolases in mice with transplantable lymphatic leukemia P 388.

Mice--BDF, hybrides, males aged 3 months were injected intraperitoneally with 10(4) lymphatic leukemia cells P 388. The mice were killed by bleeding after 2.5 and 10 days after the injection.