Publications by authors named "R Sivapackianathan"
Article Synopsis
- The study aimed to identify key biological processes affected in the subcutaneous fat tissue of patients with familial combined hyperlipidemia (FCHL), revealing a unique FCHL transcriptome involved in various systems like cytoskeleton and lipid regulation.
- Expression levels of the cell-cycle inhibitor CDKN2B were found to be elevated, and its knockdown in lab cells increased lipid accumulation, indicating a link between CDKN2B and fat storage.
- The research suggests that dysfunctional fat tissue development is a critical aspect of FCHL, although other external factors might also contribute to the increased CDKN2B expression and lipid problems in these patients.
Background: Elevated high-density lipoprotein cholesterol (HDL-C) is associated with reduced risk of cardiovascular disease, and variation in HDL-C levels has been shown to be approximately 50% heritable. Overexpression of endothelial lipase (EL), a member of the lipoprotein lipase gene family, markedly reduces HDL-C levels in mouse models. We hypothesized that genetic variation in EL might be associated with elevated HDL-C.
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